Location: GLUT demo for CFDE Summer School in Mechanistic Modeling for PBPK Transport @ 122156a3c2e6 / Simulation protocols.txt

Author:
Weiwei Ai <wai484@aucklanduni.ac.nz>
Date:
2025-08-25 17:10:11+12:00
Desc:
Add ss_oi which will be for the demo
Permanent Source URI:
https://staging.physiomeproject.org/workspace/d5c/rawfile/122156a3c2e622ae9ae86ac6a8cca36c77cac68a/Simulation protocols.txt

Simulation protocols for GLUT_ss_oi.sedml:

1. As $g_i$ changes from 1 to 50 mM, the steady-state values of $v$ shift from negative (indicating transport from intracellular to extracellular) to positive (indicating transport from extracellular to intracellular).

2. As $K_{Ai}$ increases from 149.65 to 500 per fmol, a negative flow rate (from intracellular to extracellular) is observed when $g_i = g_o$, indicating thermodynamically inconsistent parameters.

3. As $\kappa_{r1}$ increases from 0.36 to 100 fmol/s, the v_max doesn't change, while the MM constant changes.